Therefore, the present study was designed to characterize the biochemical and physiological parameter for its possible biological effects and safety at long time administration of fruit juice of murraya koenigii in terms of 28 days repeated dose toxicity study. Screening of invitro hypoglycemic activity of murraya koenigii and. Murraya koenigii is semi deciduous, aromatic smell spreading shrub or tree with strong woody stem but slender with the stem which is dark green to brownish in color the tree is 48. Hypoglycemic activity of murraya koenigii meethaneem leaves. The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes article pdf available. Antioxidative activity of carbazoles from murraya koenigii leaves. Antihyperglycemic activity of murraya koenigii leaves extract.
Comparative study of in vitro antioxidant and antidiabetic activity of plant extracts of acacia arabica murraya koeingii catharanthus. Protective effect of murraya koenigii l leaves extract in. Leaves of murraya koengii was used for the flavouring purpose. Open in a separate window antimicrobial efficacy of extracts all the six double combinations of the plant extracts were effective in inhibiting the growth of s.
However, there is a need to conduct further pharmaceutical analysis on test extracts in order to establish these biomedical applications. Murraya koenigii has diverse role in traditional medicine and is known for its stomachic properties. The highly valued part of the plant is the leaves which possess various biological activities. The antioxidant activity in murraya koenigii is mainly attributed to carbazole alkaloids tachibana et al. Phytochemical portfolio and anticancer activity of murraya. Their properties include much value as an antidiabetic 91 and hepatoprotectant 92. Antidiabetic activity of some herbal plants in streptozotocin. As an herb, it offers potential uses in fat loss such as.
The antidiabetic properties and phytochemical studies of fractions of ethanolic leaf extract 400mgkgb. Evaluation of antidiabetic activity of murraya koenigii on alloxan. Studies on carbazoles isolated from murraya koenigii leaves have been shown to possess antioxidant and antimicrobial activity 93 95. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats article pdf available in international journal of pharmaceutical sciences and. Introduction murraya koenigii, commonly known as curry leaf or kari patta in indian dialects, belonging to family rutaceae which represent more than 150 genera and 1600 species1. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. The chlorhexidine produced the least inhibition zone against s. Hypoglycemic activity studies on root extracts of murraya koenigii root in alloxaninduced diabetic rats sweety lanjhiyana 1, debapriya garabadu 2, dheeraj ahirwar 1, papiya bigoniya3, avtar chand rana 4, kartik chandra patra 2, sanjay kumar lanjhiyana 2 and murugan karuppaih 5. The treatment of diabetes type ii is complicated due to the inherent pathophysiological factors related to this disease. The methylene chloride ch2cl2 extract and the ethyl acetate etoac soluble fraction of the 70% acetone extract significantly prolonged the osi values. The stzna diabetic rats were treated with an ethanolic extract of murraya koenigii 200 mgkg b.
The present study was carried out to evaluate the antidiabetic effect and histological parameters of. This study was to evaluate the ethnomedical uses of the stem bark in in. Pdf the antidiabetic activity of curry leaves murraya. Thin layer chromatography, murraya koenigii bark, phytochemical screening.
Murraya koenigii can be used to cure the symptoms of variety of diseases. Pdf the antidiabetic activity of curry leaves murraya koenigii. Yankuzoa adepartment of basic medical science, kulliyyah of medicine, international islamic university malaysia. It contains several bioactive compounds like euchrestine b, bismurrayafoline e, mahanine, mahanimbicine, mahanimbine 8 and essential oil 9 which contribute to antioxidative, hypoglycaemic, antitrichomonal, blood protective and hepatoprotective effects. Antioxidant effects of curry leaf, murraya koenigii and mustard seeds, brassica juncea in rats fed with high fat diet. Hypoglycemic effects of murraya koenigii on normal and. Murraya koenigii is found in himalaya, sikkim, kerala, tamil nadu, andhra pradesh, maharashtra and assam2. Murraya koenigii curry leaf may bring blood sugarbalancing activity to weight loss formulas.
Mk, pg and cr are given to the stz induced diabetic rats at the concentration of 500 mgkg body weight in different groups of 6 diabetic rats each orally once a day for 15 days. Pdf antidiabetic effect of murraya koenigii leaves on. Hydroalcoholic and alkaloidal extracts of murraya koenigiil. Since adequate characterization of antidiabetic activity of murraya koenigii aqueous extract has not yet been done and considering that highest amount of brcs was found to be present in murraya koenigii leaves, an attempt was made to investigate the antihyperglycaemic activity of aqueous extract of murraya koenigii leaves and compare it with. The murraya species has richest source of carbazole alkaloids. Pdf evaluation of thrombolytic activity of murraya. Murraya koenigii, commonly known as curry leaves is native to india.
The structure of koenoline 64, which was obtained for the first time as a natural product, was established with the aid of. Asin the present study, murraya koenigii meethaneem leaves collected from udaipur, rajasthan aqueous slurry exhibited a statistically significant p value koenigii have been used in traditional or folk medicine for the treatment of rheumatism, traumatic injury and snake bite and it has been reported to have antioxidant, antidiabetic, antidysenteric, antimicrobial, antiinflammatory, hepatoprotective and antihypercholesterolemic activities11,12. The present study was aimed to evaluate the antidiabetic effect of murraya koenigii leaves chloroform extract mklce in alloxan. Evaluation of antidiabetic activity of murraya koenigii on.
Murraya koenigii is an aromatic and more or less deciduous shrub or small tree up to 7 meters in height and 14 to 42 cm in diameter raghunathan, et al. India is considered as the worlds diabetic capital. Traditionally, the leaves are used as a herb in ayurvedic medicine. One of the complications of diabetes is postprandial hyperglycemia pphg. Phytochemical portfolio and anticancer activity of murraya koenigii and its primary active component, mahanine. Leaves of the plant have much value as an antidiabetic, antioxidant, antimicrobial, anti. This plant is promising as it is widely and regularly used as a spice for food flavoring and as such it appears to be without any side effects and toxicity. References patel d, patel hn, pathak k, venkatraghvan s, pharmacy education series. Koja bay leaves murraya koenigii which mostly cultivated in indonesia and the leaves usually used by aceh people as a flavoring agent for food, has been known to have an antidiabetic effectin this study, we analyzed the antidiabetic effect of koja bay leaves tea bags which commercially available. The commonly used spice curry patta murraya koenigii is traditionally consumed by diabetics in southern part of india.
The two variant doses of koja bay leaves tea bag 411. Protective effect of murraya koenigii leaves extract instreptozotocin induced diabetic rats involving possible antioxidant mechanism. Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and. The leaves of murraya koenigii are also used as an ingredient in ayurvedic medicine. This is the simplest known group of carbazole alkaloids. The aqueous extract of the leaves of murraya koenigii after oral as well as intravenous administration to normal and alloxan diabetic dogs produced the hypoglycemia. The present study aimed to investigate the antidiabetic effect of murraya koenigii mk leaf extracts, of two different solvent ratios. Various parts of murraya koenigii have been used in traditional or folk medicine for the treatment of rheumatism, traumatic injury and snake bite 2. It belongs to family rutaceae which represent more than 150 genera and 1600 species. Glibenclamide was used as a standard reference drug. Introduction murraya koenigii, commonly known as curry leaf or karipatta in indian dialects, belonging to family rutaceae which represent more than 150. Suvagiya 5 faculty of pharmaceutical sciences, pacific university 1, udaipur, rajasthan, india. The present study was aimed to evaluate the antidiabetic effect of murraya koenigii leaves chloroform extract mklce in alloxaninduced diabetic albino rats model. The medicinal plant murraya koenigii shown to have a wide variety of pharmacological activities hypoglycemic and hypolipidemic.
Potential antidiabetic herbal medicines html full text. Husna f12, suyatna fd3, arozal w3, poerwaningsih eh4. Antidiabetic potential of murraya koenigii roots in. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats dr. Herbal antidiabetic drugs are prescribed widely because of their effectiveness, less side effects and relatively low cost19. Naturally occurring carbazole alkaloids from murraya. Hypoglycemic and antihyperglycemic activity of murraya. Hypoglycemic activity studies on root extracts of murraya koenigii root in alloxaninduced diabetic rats sweety lanjhiyana 1, debapriya garabadu 2, dheeraj ahirwar 1, papiya bigoniya3, avtar chand rana 4, kartik chandra patra 2, sanjay kumar lanjhiyana 2 and murugan karuppaih 5 1school of pharmacy, chouksey engg. The aqueous extract of murraya koenigii leaves has been taken to evaluate the hypoglycemic activity in normal and alloxan induced diabetic rabbits. Phytochemical profile of murraya koenigii leaves shows the presence of some vitamins, carbazole alkaloids, triterpenoids, mineral contents such as iron, calcium, zinc and vanadium, and phenolic compounds chakrabarty et al. Conclusions the present study reveals that murraya koenigii possesses antidiabetic activity and antioxidant effects on stz. Previous studies reported koja bay leaves has many pharmacological activities such as antidiabetic, antihypertension, anti. Antidiabetic activity of curry leaves murraya koenigii on.
Hypoglycemic activity studies on root extracts of murraya. Activity of proline and its analogs isolated from murraya. Antidiabetic and hypolipidemic effects of mahanimbine carbazole alkaloid from murraya koenigii rutaceae leaves. The in vitro thrombolytic property of curry leaves murraya koenigii and palak spinacia oleracea was determined by using human blood. Evaluation of antidiabetic effect of murraya koenigii.
Antidiabetic effect of murraya koenigii leaves aqueous. Green leafy vegetable consumption has been associated with decreased risk of persistent metabolic diseases. Protective effect of murraya koenigii l leaves extract in streptozotocin induced diabetics rats involving possible antioxidant mechanism s. A study on a highly medicinal plant murraya koenigii. Antidiabetic activity of curry leaves murraya koenigii on glucose level, kidney and islets of langerhans in streptozotocin induced diabetes in rats imad m. Aqueous extract of leaves of 3 herbs murraya koenigii, mk. Evaluation of antidiabetic effect of murraya koenigii leaves. Psidium guajava, pg and catharanthus roseus, cr were used to test their antidiabetic activity in streptozotocin stz induced diabetic albino rats. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats article pdf available in international journal of pharmaceutical sciences and research 612. Sakarkar department of pharmacology and physiology sudhakarrao naik institute of pharmacy, nagpur road, pusad 445204 m. Murraya koeinigii for its any biological activities. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Research article total phenolic content estimation.
The scientific evaluation of hypoglycemic and antidiabetic activity of freeze dried leaves of murraya koenigii was carried out in normal and streptozotocininduced sub and mild diabetic rats. The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced. Thus the aim of the present work was to evaluate the antidiabetic activity of fruit juice of murraya koenigii. Antidiabetic potential of murraya koenigii roots in alloxan. Antioxidative activity of carbazoles from murraya koenigii. Antidiabetics activity of salam koja murraya koenigii. Effect of murraya koenigii leaf extract on carbohydrate. These include antioxidant, antidiabetic, antiinflammatory, antitumor. The antidiabetic activity of curry leaves murraya koenigii on the. Arulselvan p1, senthilkumar gp, sathish kumar d, subramanian s. Present work conducted on murraya koenigii illustrates its antidiabetic and antioxidant activities using various biochemical tests. Antidiabetic activity of herbal drugs dwiti modak ayurvedic pharmacy, lovely school of pharmaceutical sciences, lovely professional university, phagwara, punjab, india dwiti.
International journal of pharma and bio sciences v122010. Antidiabetic effect of murraya koenigii ksu faculty. Murraya koenigii leaf extract inhibits proteasome activity. Pharmacological activities of murraya koenigii and its primary bioactive. Naturally occurring carbazole alkaloids from murraya koenigii. Phytochemical investigation of aqueous aemk and methanolic memk extracts of murraya koenigii were screened for the presence of phytoconstituents like phenolics, flavonoids, saponins, alkaloids, and glycosides.
Evaluation of antidiabetic efficacy of murraya koenigii on streptozotocin. Feeding of diet containing various doses of curry leaves 5, 10 and 15% to normal rats for 7 days as well as mild diabetic blood glucose levels 175 mgdl induced by alloxan 35 mgkg ip and moderate diabetic rats blood glucose levels 250 mgdl induced by stz 60 mgkg ip. Murraya koenigii is a potential medicinal plant highly valued for its characteristic aroma and bioactive compounds. Antidiabetic effect of murraya koenigii l and olea. After the administration of murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Pdf evaluation of antidiabetic activity of murraya koenigii. Evaluation of antidiabetic activity of murraya koenigii on alloxan induced diabetic rats. The antioxidative properties of the leaves extracts of murraya koenigii using different solvents were evaluated based on the oil stability index osi together with their radical scavenging ability against 11diphenyl2picrylhydrazyl dpph. In the present study, antihyperglycemic effect of oral administration of ethanolic extract of m. The study of plants having antidiabetic activity may give a new idea in the approaches of diabetes mellitus treatment.
Medicinal profile, phytochemistry, and pharmacological. However, interesting to isolate the compounds responsible for antidiabetic activity and to elucidate their mechanism of action. Hypoglycemic activity of murraya koenigii meethaneem. Pdf antidiabetic properties and phytochemical studies. Pharmacological properties of the extract and some isolated. The antidiabetic activity of curry leaves murraya koenigii on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes article pdf available august. Anticolon cancer activity of murraya koenigii leaves is due to constituent murrayazoline and omethylmurrayamine a induced mtorakt downregulation and mitochondrial apoptosis. In addition, murraya koenigii exhibited a pro found antioxidant effect with decreased mda level and increased gsh level, particularly at the 200 mgkg b. Assessment of antidiabetic and antioxidant activity of. The results was comparable to standard compound glibenclamide. Evaluation of antidiabetic efficacy of murraya koenigii on.
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